Reproductive genomics - latest announcements

Mutants announced 5/14/07
Nine mapped mutant mouse models of infertility are now available

Click on the gene/family identification number below to view new postings or go to the mutant lists to see all available mutants:

1. repro2/G1-374-15 male infertile, mapped to Chromosome 5

2. repro3/G1-397-28 male infertile, mapped to Chromosome 10

3. repro4/G1-397-34 male infertile, mapped to Chromosome 1

4. repro7/G1-419-29 male and female infertile, mapped to Chromosome 17

5. repro14/G1-449-31 male and female infertile, mapped to Chromosome 5

6. ferf1/G1-415-19 male infertile, mapped to Chromosome 14

7. repro36/G1-569-2 male and female infertile, mapped to Chromosome 9

8. repro46/G1-565-6 male and female infertile, mapped to Chromosome 9

9. repro57/G1-586-2 male infertile, mapped to Chromosome 5

Five mapped mutant mouse models of infertility are being cryopreserved and will be off the shelf by 5/25/07

1. repro17/G1-464-23  mapped to Chromosome 17

2. repro22/G1-453-4  mapped to Chromosome 4

3. repro23/G1-476-14  mapped to Chromosome 7

4. repro29/G1-485-3  mapped to Chromosome 5

5. repro33/G1-538-5  mapped to Chromosome 16

ReproGenomics mutant mouse model publications

Bannister L, Pezza R, Donaldson R, de Rooij D, Schimenti K, Camerini-Otero D, Schimenti JC. Male-specific sterility in mice carrying a dominant, recombination-defective allele of the RecA homolog Dmc1. PLoS Biol. 2007 Apr 10;5(5):e105.

Lessard C, Lothrop H, Schimenti JC, Handel MA. Mutagenesis-generated mouse models of human infertility with abnormal sperm. Hum Reprod. 2007 Jan;22(1):159-66. Epub 2006 Aug 18.

Handel MA, Lessard C, Reinholdt L, Schimenti JC, Eppig JJ.  Mutagenesis as an unbiased approach to identify novel contraceptive targets.  Mol Cell Endo. 2006; 250:201-205.

Lessard C, Pendola JK, Hartford SA, Schimenti JC, Handel MA, Eppig JJ.  New mouse genetic models for human contraceptive development.  Cytogenet Genome Res. 2004; 105:222-227.