Reproductive Genomics: Mutant Mouse Models of Infertility

Mouse and DNA HelixThe Reproductive Genomics Program at The Jackson Laboratory is funded by a Program Project grant from the Institute of Child Health and Human Development PO1 HD42137.  It is a collaborative effort among the laboratories of John Eppig, Mary Ann Handel, and John Schimenti. The goal is to use random chemical mutagenesis of the genome to produce mouse models of infertility. At least 800 families of mice will be screened for infertility mutations over a total period of 5 years in a strategy that is estimated to produce over 100 mutant models.

The scope of this NIH funded program includes ENU mutagenesis of the mouse genome, phenotypic screening for infertility mutations, and regional mapping of each mutation to a chromosome. In addition, the program will conduct a basic phenotype analysis of each mutant to classify the nature of the defect.

The Reproductive Genomics Program will provide breeding stock to scientists interested in utilizing these models in their own research programs.

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