Gene Family ID # Chromosome Chromosome Region*
(NCBI Build 34)
Status Post Date
Flanking Markers Base Pair
repro22 G1-453-4 Chr 4 D4Mit54 to D4Mit42 136771799-150062357 Cryopreserved 1/4/05
Male
Phenotype

In vitro clinic: Very low testis weight, no epididymal sperm recovered.

Histology evaluation: Germ cell depletion, spermatogonia present but no later spermatogenic stages (see 1-2).

Female
Phenotype

In vitro clinic: No oocytes recovered.

Histology evaluation: Tiny ovaries (see 3-4).

Instructions for viewing candidate genes for this mutant line

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 Depleted germ cells  Depleted germ cells  
  1. Whole testis: depletion of germ cells   2. Germ cell depletion  
 Tiny ovary 10X  Tiny ovary 40X  
  3. Tiny ovary (4X)   4. Tiny ovary (40X)  

*The scope of our funding includes mapping of the mutation to a chromosomal region, but in most cases does not include cloning of the gene responsible for the infertile phenotype.