The Bult Lab

Our research focus

Integrating sequence and biology in the Mouse Genome Informatics (MGI) database

I am a principal investigator in the MGI consortium at The Jackson Laboratory. The mission of MGI is to build information systems that facilitate the use of the mouse as a model system for understanding human biological processes and disease through the integration of diverse genetic and genomic data. Within MGI, my group has as its mission to connect mouse sequence data with the wealth of biological knowledge about mouse genes available in the MGI database. We accomplish our mission by:

• Curating associations between sequences and genes;
• Building a complete and non-redundant catalog of mouse genes;
• Associating genes in MGI with relevant data in external databases;
• Supporting sequence-based queries of MGI using our customized MouseBLAST server; and
• Supporting the generation of customized data sets of sequences using biologically meaningful criteria (e.g., "Return all protein sequences for genes on Chromosome 2 that have been annotated as transcription factors").